REM sleep behavior disorder: from dreams to neurodegeneration.
Identifieur interne : 001143 ( Main/Exploration ); précédent : 001142; suivant : 001144REM sleep behavior disorder: from dreams to neurodegeneration.
Auteurs : Ronald B. Postuma [Canada] ; Jean-Francois Gagnon ; Jacques Y. MontplaisirSource :
- Neurobiology of disease [ 1095-953X ] ; 2012.
English descriptors
- KwdEn :
- Animals, Autonomic Nervous System Diseases (etiology), Autonomic Nervous System Diseases (physiopathology), Biomarkers, Humans, Lewy Body Disease (complications), Neurodegenerative Diseases (pathology), Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (psychology), Parkinson Disease (complications), REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (epidemiology), REM Sleep Behavior Disorder (pathology), REM Sleep Behavior Disorder (physiopathology), REM Sleep Behavior Disorder (psychology), Sleep (physiology), Sleep, REM (physiology), Substantia Nigra (pathology), Substantia Nigra (physiopathology), Vision Disorders (etiology), Vision Disorders (physiopathology).
- MESH :
- chemical : Biomarkers.
- complications : Lewy Body Disease, Parkinson Disease.
- diagnosis : REM Sleep Behavior Disorder.
- epidemiology : REM Sleep Behavior Disorder.
- etiology : Autonomic Nervous System Diseases, Vision Disorders.
- pathology : Neurodegenerative Diseases, REM Sleep Behavior Disorder, Substantia Nigra.
- physiology : Sleep, Sleep, REM.
- physiopathology : Autonomic Nervous System Diseases, Neurodegenerative Diseases, REM Sleep Behavior Disorder, Substantia Nigra, Vision Disorders.
- psychology : Neurodegenerative Diseases, REM Sleep Behavior Disorder.
- Animals, Humans.
Abstract
REM sleep behavior disorder is a unique parasomnia characterized by dream enactment behavior during REM sleep. Unless triggered by pharmacologic agents such as antidepressants, it is generally related to damage of pontomedullary brainstem structures. Idiopathic REM sleep behavior disorder (RBD) is a well-established risk factor for neurodegenerative disease. Prospective studies have estimated that at least 40-65% of patients with idiopathic RBD will eventually develop a defined neurodegenerative phenotype, almost always a 'synucleinopathy' (Parkinson's disease, Lewy Body dementia or multiple system atrophy). In most cases, patients appear to develop a syndrome with overlapping features of both Parkinson's disease and Lewy body dementia. The interval between RBD onset and disease onset averages 10-15 years, suggesting a promisingly large window for intervention into preclinical disease stages. The ability of RBD to predict disease has major implications for design and development of neuroprotective therapy, and testing of other predictive markers of synuclein-mediated neurodegeneration. Recent studies in idiopathic RBD patients have demonstrated that olfaction, color vision, severity of REM atonia loss, transcranial ultrasound of the substantia nigra, and dopaminergic neuroimaging can predict development of neurodegenerative disease.
DOI: 10.1016/j.nbd.2011.10.003
PubMed: 22019718
Affiliations:
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Postuma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. ronald.postuma@mcgill.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name></author><author><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y" last="Montplaisir">Jacques Y. Montplaisir</name></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autonomic Nervous System Diseases (etiology)</term><term>Autonomic Nervous System Diseases (physiopathology)</term><term>Biomarkers</term><term>Humans</term><term>Lewy Body Disease (complications)</term><term>Neurodegenerative Diseases (pathology)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neurodegenerative Diseases (psychology)</term><term>Parkinson Disease (complications)</term><term>REM Sleep Behavior Disorder (diagnosis)</term><term>REM Sleep Behavior Disorder (epidemiology)</term><term>REM Sleep Behavior Disorder (pathology)</term><term>REM Sleep Behavior Disorder (physiopathology)</term><term>REM Sleep Behavior Disorder (psychology)</term><term>Sleep (physiology)</term><term>Sleep, REM (physiology)</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (physiopathology)</term><term>Vision Disorders (etiology)</term><term>Vision Disorders (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Vision Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurodegenerative Diseases</term><term>REM Sleep Behavior Disorder</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sleep</term><term>Sleep, REM</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Neurodegenerative Diseases</term><term>REM Sleep Behavior Disorder</term><term>Substantia Nigra</term><term>Vision Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Neurodegenerative Diseases</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">REM sleep behavior disorder is a unique parasomnia characterized by dream enactment behavior during REM sleep. Unless triggered by pharmacologic agents such as antidepressants, it is generally related to damage of pontomedullary brainstem structures. Idiopathic REM sleep behavior disorder (RBD) is a well-established risk factor for neurodegenerative disease. Prospective studies have estimated that at least 40-65% of patients with idiopathic RBD will eventually develop a defined neurodegenerative phenotype, almost always a 'synucleinopathy' (Parkinson's disease, Lewy Body dementia or multiple system atrophy). In most cases, patients appear to develop a syndrome with overlapping features of both Parkinson's disease and Lewy body dementia. The interval between RBD onset and disease onset averages 10-15 years, suggesting a promisingly large window for intervention into preclinical disease stages. The ability of RBD to predict disease has major implications for design and development of neuroprotective therapy, and testing of other predictive markers of synuclein-mediated neurodegeneration. Recent studies in idiopathic RBD patients have demonstrated that olfaction, color vision, severity of REM atonia loss, transcranial ultrasound of the substantia nigra, and dopaminergic neuroimaging can predict development of neurodegenerative disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y" last="Montplaisir">Jacques Y. Montplaisir</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. 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